A Single Arm Feasibility Study of Exercise for Improving Long-course Chemoradiotherapy Efficacy in People With Locally Advanced Rectal Cancer

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Early Phase 1
SUMMARY

This is a single arm feasibility study of exercise for improving long- course neoadjuvant chemoradiotherapy (NACRT) efficacy in people diagnosed with locally advanced rectal cancer. The study aims to recruit up to 30 patients from the Queen's Centre for Oncology and Haematology of Castle Hill Hospital, Cottingham, diagnosed with locally advanced rectal cancer. Consenting patients will be provided with an 11-week course of structured aerobic exercises and resistance training in the periods before, during and after their chemoradiotherapy treatment. The patients will be followed up for 6 months post long course neoadjuvant chemoradiotherapy (NACRT), with a total of 3 assessment periods.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• 18 years or older

• Have been diagnosed with locally advanced rectal cancer using MRI (Magnetic Resonance Imaging) and histological finding

• Have been offered long-course neoadjuvant chemoradiotherapy in the Queens Centre, Castle Hill Hospital

• Willing and able to comply with all study requirements

• Able and willing to voluntarily give informed consent to take part.

Locations
Other Locations
United Kingdom
Castle Hill Hospital
RECRUITING
Cottingham
Contact Information
Primary
Chizitara Amadi
CHIZITARA.AMADI-2021@hull.ac.uk
07887391904
Backup
John Saxton
john.saxton@hull.ac.uk
Time Frame
Start Date: 2024-12-10
Estimated Completion Date: 2026-02-28
Participants
Target number of participants: 30
Treatments
Experimental: Single arm feasibility
This study involves a single arm only. Therefore all consenting participants will receive the exercise intervention detailed in the protocol.~The exercise interventions include an 11-week aerobic and resistance training delivered 2-weeks before chemoradiotherapy commences , in the 5-weeks of chemoradiotherapy and 4 weeks following chemoradiotherapy.~2-days Aerobic exercise will be delivered on vigorous intensity on a cycle ergometer. This will be under the supervision of a trained physiotherapist. 2-days Resistance training will be home based with guidance of an exercise sheet.
Related Therapeutic Areas
Colorectal Cancer
Sponsors
Collaborators: Hull University Teaching Hospitals NHS Trust
Leads: University of Hull

This content was sourced from clinicaltrials.gov

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